From the Quad, travel the series of ramps along the east side and south side of Alkek Library that rise to a mall area between Alkek Library and the Alkek Teaching Theater. Travel the ramp directly across from Alkek Library west to the LBJ Student Center and Visitors Center (LBJSC). Follow the ramp past the LBJSC water fountain in front of the Texas State Bookstore. This ramp leads to a series of ramps across the Comanche Street bridge. Supple Science is located on the south side of the bridge.
Accessible parking is located on the south side of the building.
The 2nd floor main entrance of the building faces north and has a semi-automatic door. The 1st floor entrance faces south and has a semi-automatic door.